Studies
Current Endometriosis Research
Understanding endometriosis requires access to reliable, up-to-date research. This section is for those who want to explore the evidence behind current knowledge. This study site is a curated, searchable research index for endometriosis-specific publications, clinical studies, and related research topics. It includes ongoing and completed studies, opportunities to participate in research, and a structured view of how the scientific landscape is developing.
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Studies you can join
Clinical studies seeking participants
Currently recruiting
ELECTRE
A single-center randomized study evaluating the efficacy and tolerability of a transcutaneous electrical nerve stimulation (TENS) device for managing endometriosis-associated pelvic pain. The study compares conventional TENS with microstimulation TENS and is recruiting adult women with endometriosis and/or adenomyosis diagnosed by imaging and/or histology.
EndoSolve
OnaWave Medical is developing a novel, non-invasive and painless method for faster diagnosis of endometriosis through analysis of subtle bioelectric rhythms in the pelvis. Built on research from University of Galway and supported by the European Innovation Council.
Recruitment ended - results pending
NOVA – Vipoglanstat (Phase 2)
A randomized, double-blind, placebo-controlled Phase 2 trial by Swedish biotech Gesynta Pharma investigating Vipoglanstat, a non-hormonal and non-opioid compound, for endometriosis-associated pain. Approximately 190 women aged 18–45 are being enrolled across multiple European centers to evaluate efficacy, safety, and optimal dosing.
Endogreet
A potential non-hormonal treatment approach using Tigovit, a green tea extract, in a randomized, double-blind, placebo-controlled study at MedUni Vienna. Green tea extract has shown promise in reducing both pain and inflammation around endometriosis lesions.
IMAGENDO
Imaging study aiming to reduce endometriosis diagnosis time through improved imaging analysis. Participants needed pelvic MRI or transvaginal ultrasound examinations.
ENDOFLEX
A MedUni Vienna study investigating Flexofytol, a curcumin extract preparation, as a potential non-hormonal approach for endometriosis-associated pain. The rationale was based on the inflammatory component of endometriosis symptoms and prior clinical data suggesting anti-inflammatory and antioxidant pain-relief effects of curcumin preparations in osteoarthritis.
Published Endometriosis Research
Browse curated endometriosis publications across various categories. Each entry links back to the original publication source.
153 publications
Review proposing that endometriosis lesions develop through multiple routes: retrograde menstruation, embryonic stem cell remnants, stem cell recruitment, and genetic/epigenetic modifications. Different genetic risk combinations may predispose individuals to different routes of lesion development, contributing to disease heterogeneity. Advocates for molecular profiling and patient-derived organoid models to advance research.
Jun 1, 2026
Exploratory phase 2 DETECT study evaluating 99mTc-maraciclatide SPECT-CT imaging, a radiotracer approach targeting αvβ3 integrins associated with angiogenesis, in participants with suspected or confirmed pelvic or thoracic endometriosis. Among 19 participants who completed both imaging and surgery, imaging findings were concordant with the surgical presence or absence of endometriosis in 16 cases. Endometriosis was imaged in 14 of 17 surgically positive participants, including thoracic disease. The study suggests potential for detecting superficial peritoneal endometriosis that conventional imaging may miss, but the sample was small and larger phase 3 validation is still required.
Apr 29, 2026
Largest multi-ancestry GWAS and integrated multi-omics study of endometriosis to date, analyzing ~1.4 million women including 105,869 cases. The study identified 80 genomic risk loci, including 37 new loci, and linked risk signals to pathways involved in cell differentiation, immune and hormonal regulation, tissue remodeling, and inflammation. It also found partial genetic overlap with adenomyosis and interactions between polygenic endometriosis risk and symptoms such as abdominal pain, anxiety, migraine, and nausea; these findings are association-based and do not imply deterministic prediction for individual patients.
Apr 29, 2026
Review reframing endometriosis as a systemic disorder of distributed network dysregulation rather than a purely pelvic condition. The authors map reciprocal signalling between aberrant sensory nerve growth and dysfunctional immune responses as key events in lesion development and sustained pain. This neuroimmune crosstalk shapes epithelial and stromal behaviour, amplifies inflammation, and reinforces pain circuitry. They propose that targeting key neuroimmune nodes may offer new therapeutic opportunities to curb both lesion progression and endometriosis-related chronic pain.
Mar 26, 2026
Preprint study showing elevated transferrin and its receptor in endometriotic cells alongside reduced antioxidant capacity. Experimental knockdown of transferrin suppressed cell proliferation and migration while increasing apoptosis, implicating the transferrin/ferroptosis axis in disease pathogenesis. Findings are preliminary and have not yet undergone peer review.
Mar 16, 2026
Book chapter synthesizing precision medicine approaches to endometriosis, integrating pain phenotyping, molecular and inflammatory biomarkers, and mechanisms of treatment resistance. The authors review targeted pharmacologic strategies including neuromodulators, selective progesterone receptor modulators, immunomodulatory and anti-fibrotic agents, and non-hormonal therapies under investigation. The chapter provides a mechanism-based framework for individualized treatment grounded in neuroinflammation, peripheral and central sensitization, and immune dysregulation.
Mar 2, 2026
Endopaedia Knowledge Map
Visual representation of curated scientific papers across research categories
Bubble size reflects number of papers. Double border indicates recent additions.
Mechanisms
46 papers(+2 new)
Natural Compounds
36 papers
Pain & Sensitization
22 papers
Drugs & Pharmaceuticals
20 papers
Diagnostics & Biomarkers
19 papers(+1 new)
Comorbidities
14 papers
Surgical Techniques
11 papers
Epidemiology
10 papers
Genetics & Genomics
9 papers(+1 new)
Interventions
8 papers
Microbiome
7 papers
Fertility & Reproduction
4 papers
Devices & Physical Care
2 papers
Research Network
Connections between papers based on shared MeSH keywords
Each dot is a published study. Studies that share research topics are connected by lines — the more topics in common, the stronger the connection. Clusters reveal where science is most active and how different areas of endometriosis research are interrelated. Hover over any dot to view the paper title.