Studies

Women with endometriosis show significantly elevated risks for depression, anxiety disorders, and substance use disorders. Notably, postoperative hormonal therapy did not reduce psychiatric risk, highlighting the need for integrated gynecologic and psychological care.

Analysis of over 40,000 endometriosis patients across six University of California medical centers identified hundreds of significantly associated conditions including genitourinary disorders, neoplasms, and autoimmune diseases. Clustering analyses revealed distinct patient subpopulations with psychiatric and autoimmune comorbidity patterns.

This review explores how endometriosis elevates cardiovascular disease risk through chronic systemic inflammation, endothelial dysfunction, oxidative stress, and metabolic disturbances. The authors emphasize that a multidisciplinary approach involving gynecologists, cardiologists, and primary care providers is essential for managing these interconnected conditions.

Systematic review and meta-analysis of seven studies involving over 1.4 million participants examining cardiovascular risk in women with endometriosis. Women with endometriosis showed significantly elevated risks for cerebrovascular disease (HR 1.19), ischemic heart disease (HR 1.35), major adverse cardiovascular events (HR 1.15), and arrhythmias (HR 1.21). No significant association was found with heart failure or all-cause mortality.

Bidirectional Mendelian randomization using GWAS data found periodontitis positively associated with endometriosis of the pelvic peritoneum (OR=1.079, p=0.014). No causal relationships with other endometriosis subtypes. Reverse analysis found no evidence that endometriosis causes periodontitis.

Survey-based study of 346 endometriosis patients and 155 controls examining relationships with allergic and autoimmune disorders. Found significant differences in family history of endometriosis, onset of allergic symptoms, frequency and duration of abdominal pain, and defecation disorders between groups.

Editorial discussing how endometriosis patients suffer lengthy diagnostic delays partly due to overlapping symptomology with other diseases. Reviews associations between endometriosis and various malignancies, as well as comorbid pain conditions including bladder pain syndrome, irritable bowel syndrome, and vulvodynia.

Review examining how endometriosis interacts with cardiovascular risk factors and cardiovascular disease. Highlights systemic hormonal, pro-inflammatory, pro-angiogenic, immunologic, and genetic processes in endometriosis pathophysiology that may contribute to cardiovascular risk in affected women.