Studies
Current Endometriosis Research
Understanding endometriosis requires access to reliable, up-to-date research. This section is for those who want to explore the evidence behind current knowledge — including ongoing and completed studies, opportunities to participate in research, and a structured view of how the scientific landscape is developing.
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Studies you can join
Clinical studies seeking participants
Currently recruiting
ELECTRE
A single-center randomized study evaluating the efficacy and tolerability of a transcutaneous electrical nerve stimulation (TENS) device for managing endometriosis-associated pelvic pain. The study compares conventional TENS with microstimulation TENS and is recruiting adult women with endometriosis and/or adenomyosis diagnosed by imaging and/or histology.
EndoSolve
OnaWave Medical is developing a novel, non-invasive and painless method for faster diagnosis of endometriosis through analysis of subtle bioelectric rhythms in the pelvis. Built on research from University of Galway and supported by the European Innovation Council.
Recruitment ended - results pending
NOVA – Vipoglanstat (Phase 2)
A randomized, double-blind, placebo-controlled Phase 2 trial by Swedish biotech Gesynta Pharma investigating Vipoglanstat, a non-hormonal and non-opioid compound, for endometriosis-associated pain. Approximately 190 women aged 18–45 are being enrolled across multiple European centers to evaluate efficacy, safety, and optimal dosing.
Endogreet
A potential non-hormonal treatment approach using Tigovit, a green tea extract, in a randomized, double-blind, placebo-controlled study at MedUni Vienna. Green tea extract has shown promise in reducing both pain and inflammation around endometriosis lesions.
IMAGENDO
Imaging study aiming to reduce endometriosis diagnosis time through improved imaging analysis. Participants needed pelvic MRI or transvaginal ultrasound examinations.
ENDOFLEX
A MedUni Vienna study investigating Flexofytol, a curcumin extract preparation, as a potential non-hormonal approach for endometriosis-associated pain. The rationale was based on the inflammatory component of endometriosis symptoms and prior clinical data suggesting anti-inflammatory and antioxidant pain-relief effects of curcumin preparations in osteoarthritis.
19 publications
Exploratory phase 2 DETECT study evaluating 99mTc-maraciclatide SPECT-CT imaging, a radiotracer approach targeting αvβ3 integrins associated with angiogenesis, in participants with suspected or confirmed pelvic or thoracic endometriosis. Among 19 participants who completed both imaging and surgery, imaging findings were concordant with the surgical presence or absence of endometriosis in 16 cases. Endometriosis was imaged in 14 of 17 surgically positive participants, including thoracic disease. The study suggests potential for detecting superficial peritoneal endometriosis that conventional imaging may miss, but the sample was small and larger phase 3 validation is still required.
Apr 29, 2026
First study to identify a distinct serum microRNA signature specific to adolescent and young adult endometriosis patients, differing from patterns found in adults. The identified microRNA profile may enable non-invasive early diagnosis in younger patients, addressing the current diagnostic barrier of reliance on laparoscopy. The authors propose this approach as a tool for early detection and prevention of disease progression.
Nov 24, 2025
Bioinformatics and machine learning analysis identified three apoptosis-related genes — FAS, PRKAR2B, and CSF2RB — as candidate diagnostic biomarkers for endometriosis. FAS and CSF2RB were significantly downregulated in patient samples versus controls. These genes correlated with specific immune cell populations, including B cells, dendritic cells, and myeloid-derived suppressor cells, suggesting utility both as diagnostic markers and potential therapeutic targets.
Sep 29, 2025
This preprint reports whole-genome methylation sequencing of freshly isolated menstrual blood-derived stem cells as a non-invasive approach to endometriosis diagnosis. In 42 participants (19 with endometriosis, 23 controls), differentially methylated regions (DMRs) were identified in genes linked to inflammation, tissue remodeling, and development. Machine learning models trained on these DMRs achieved 79% sensitivity and 83% specificity, supporting the potential of non-invasive epigenetic diagnostics.
Jul 26, 2025
Transvaginal ultrasound is the established method for mapping deep endometriosis, but remains operator-dependent and limited in cases of severely distorted pelvic anatomy or cul-de-sac obliteration. Through a comprehensive literature search, the authors summarize evidence on intraoperative ultrasound (IO-US) as a complementary tool, reviewing five techniques — transabdominal, transvaginal, transrectal, laparoscopic, and contact ultrasound — each suited to different surgical settings. They argue for broader adoption of IO-US to enable more precise intraoperative planning and decision-making in deep endometriosis surgery.
Mar 22, 2025
Elaborate narrative review synthesizing surgical, molecular, and computational approaches to endometriosis. Single-cell RNA sequencing reveals distinct immune, vascular, and fibrotic signatures across lesion subtypes. Proteomic and metabolomic analyses identify candidate biomarkers. AI shows promise for screening and standardizing care. The authors predict that as technology advances, surgical and medical management of endometriosis will become standardized and democratized within 2-3 decades - but emphasize that training the next generation of surgeons, clinicians, computational, epidemiologic, and wet lab researchers is essential to assure a pipeline of collaborators.
Feb 6, 2025
Endopaedia Knowledge Map
Visual representation of curated scientific papers across research categories
Bubble size reflects number of papers. Double border indicates recent additions.
Mechanisms
46 papers(+2 new)
Natural Compounds
36 papers
Pain & Sensitization
22 papers
Drugs & Pharmaceuticals
20 papers
Diagnostics & Biomarkers
19 papers(+1 new)
Comorbidities
14 papers
Surgical Techniques
11 papers
Epidemiology
10 papers
Genetics & Genomics
9 papers(+1 new)
Interventions
8 papers
Microbiome
7 papers
Fertility & Reproduction
4 papers
Devices & Physical Care
2 papers
Research Network
Connections between papers based on shared MeSH keywords
Each dot is a published study. Studies that share research topics are connected by lines — the more topics in common, the stronger the connection. Clusters reveal where science is most active and how different areas of endometriosis research are interrelated. Hover over any dot to view the paper title.